Recoverin is a 23 kDa Ca2+binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of lightstimulated phosphodiesterase activity, perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its ammo-terminus. The amino-terminal fatty acid appears to be involved in the interaction of recoverin (...) with photoreceptor membranes. (shrink)

Recoverin is a Ca2+-binding protein found primarily in vertebrate photoreceptors. The proposed physiological function of recoverin is based on the finding that recoverin inhibits light-stimulated phosphorylation of rhodopsin. Recoverin interacts with rod outer segment membranes in a Ca2+-dependent manner. This interaction requires N-terminal acylation of recoverin. Four types of fatty acids have been detected on the N-terminus of recoverin, but the functional significance of this heterogeneous acylation is not yet clear.

In describing his seven and a half years as a prisoner of war in North Vietnam, the late Vice Admiral James B. Stockdale has said: "In that atmosphere of death and hopelessness, stripped of the niceties, the amenities of civilization, my ideas on life and leadership crystallized." Despite torture, intimidation, and isolation, Stockdale fulfilled his duties as senior officer among the prisoners with intelligence and courage, defining rules of conduct and maintaining morale. He often described the intense pressures of (...) that situation as a "melting" experience, in which preconceived feelings, fears, and bias melt as one comes to realize that, under the gun, you must grow or fail—or, in some cases, grow or die. This collection of his essays and speeches from the 1980s and 1990s reinforces how that experience formed a lifelong basis for his philosophical thought on issues of character, leadership, integrity, personal and public virtue, and ethics. The selections in this volume all reflect, in one way or another, a central theme: how man can rise with dignity to prevail in the face of adversity. (shrink)

Among the more significant developments of the twentieth century, the widespread attention given to 'rights issues' must surely justify ranking it somewhere near the top. Never before has the issue of rights attracted such a wide audience or stirred so much controversy. Until very recently 'rights' were traditionally recognized as attributable only to humans. Today, we increasingly are hearing a call to extend 'rights' to the nonhuman animal and, on occasion, to the environment. In this book, James B. Reichmann, (...) S.J., undertakes an investigation of the metaethical grounds of 'rights' theory, with special focus on the controversial issue of whether creatures other than humans can and should be considered true subjects of 'rights.' He contends that before assigning rights to this or that individual or group, whether human or not, we need to be very clear about what it is we are assigning, to whom, and why. The book argues forcefully that the various recent efforts to build a case supporting animal and environmental 'rights' fail in their quest, and that any such effort resting on a Darwinian evolutionary base is likewise condemned to fail. In furtherance of this claim the author first investigates life phenomena, followed by a detailed comparative study of knowing, communicating and doing, as these are observed in the human and the nonhuman animal. This in turn is followed by an overview of diverse views advanced by contemporary environmental ethicists and animal 'rights' advocates, including Peter Singer, Tom Regan, J. Baird Callicott, Laura Westra, and Don E. Marietta, Jr. Representative though doubtless provocative conclusions drawn from this study include the claims that: (1) Classic Darwinian theory provides no admissable premise from which to derive a theory of inherent, inalienable rights. (2) No satisfactory explanation of the origin of rights and obligation can derive save from within the context of natural law theory. (3) The human person alone unqualifiedly possesses rights. (4) The view that vegetarianism is an ethical mandate is neither compatible with the Christian world view, nor philosophically sound. ABOUT THE AUTHOR: James B. Reichmann, S.J., is professor emeritus of philosophy at Seattle University where he continues to teach. (shrink)

A key question in disability studies, philosophy, and bioethics concerns the relationship between disability and well-being. The mere difference view, endorsed by Elizabeth Barnes, claims that physical and sensory disabilities by themselves do not make a person worse off overall—any negative impacts on welfare are due to social injustice. This article argues that Barnes’s Value Neutral Model does not extend to intellectual disability. Intellectual disability is (1) intrinsically bad—by itself it makes a person worse off, apart from a non-accommodating environment; (...) (2) universally bad—it lowers quality of life for every intellectually disabled person; and (3) globally bad—it reduces a person’s overall well-being. While people with intellectual disabilities are functionally disadvantaged, this does not imply that they are morally inferior—lower quality of life does not mean lesser moral status. No clinical implications concerning disability-based selective abortion, denial of life-saving treatment, or rationing of scarce resources follow from the claim that intellectual disability is bad difference. (shrink)

The publication of Ta-Nehisi Coates's "letter to his son," Between the World and Me,1 has been met with mixed and widespread reviews and reactions. Responses have ranged from a critique of his "pessimism" to a grand celebratory remark announcing him as the next great intellectual and social critic in the mold of James Baldwin.2 Yet there are few reviews that have acknowledged Coates's project as a materialist cosmology of the body. What does this mean? In short, it means that (...) while Coates embraces terrestriality over transcendence, he nevertheless sees great possibilities in the body, the greatest of which is the creation and destruction of "galaxies of reality." More than... (shrink)

Where Men Hide is a spirited tour of the dark and often dirty places men go to find comfort, camaraderie, relaxation, and escape. Ken Ross's striking photographs and James B. Twitchell's lively analysis trace the evolution of these virtual caves, and question why they are rapidly disappearing. They find that for centuries men have met with each other in underground lairs and clubhouses to conduct business or to bond and indulge in shady entertainments. In these secret dens, certain rules (...) are abandoned while others are obeyed. Twitchell connects the places men hide with figures like Hemingway and Huck Finn, Frederick Jackson Turner's theory of the American frontier, and the mythological interpretations of Joseph Campbell and Robert Bly. Documenting both traditional and contemporary male haunts, Twitchell and Ross examine the provenance, purpose, and appeal of this little-discussed and controversial phenomenon. (shrink)

It is acknowledged that Francisco Suarez had an excellent knowledge of the Medieval Scholastic tradition. In this project, I focus on one topic, human knowledge of material singulars, to determine Suarez's debt to and freedom from the Scholastic tradition. The representative thinkers of the Medieval tradition that I consider are Thomas Aquinas, John Duns Scotus, and William of Ockham. ;In the first two Chapters, I consider the accounts of John Duns Scotus and William of Ockham on the issue of knowledge (...) of singulars. I show that both Scotus and Ockham try to distance themselves from the analysis of indirect knowledge of material singulars presented by Aquinas. Although Scotus retains the notion that the universal nature is the first object of the intellect, his stress on the autonomy of the intellect in its relation to sense cognition paved the way for Ockham. Notably, Ockham rejects any account of knowledge that requires intermediary representational species, and consequently adopts a position that stresses the intellect's ability to know singulars directly via intuitive cognition. ;In the final two Chapters, I discuss in detail Suarez's account of knowledge of material singulars. I show that Suarez accepts Ockham's basic arguments for the priority of knowledge of the singular but at the same time retains the necessity of intelligible species. His account of the relationship between sense cognition and intellectual cognition owes some debt to Scotus, but Suarez accents the theme of the autonomy of the intellect to an extremely high degree. Furthermore, he rejects Ockham's account of intuitive cognition, positing instead a theory of cognition that requires representational species at every step in the cognitive process, both sensory and intellectual. Consequently, Suarez presents us with a highly nuanced and extremely consistent account of knowledge that leaves no explanatory "gaps.". (shrink)

Suppose two persons disagree over whether an act is right, justifying their judgments by appealing to divergent higher-level moral principles. These principles function as backing and rebuttals in their argumentation. To justify these principles, we may argue either that they would be accepted in some ideal model or that they are in reflective equilibrium with our considered moral judgments. Disagreement over the model indicates difference in philosophical anthropology but does not preclude resolution through argument.

In this paper I argue that selective abortion for disability often involves inadequate counselling on the part of reproductive medicine professionals who advise prospective parents. I claim that prenatal disability clinicians often fail in intellectual duty—they are culpably ignorant about intellectual disability. First, I explain why a standard motivation for selective abortion is flawed. Second, I summarize recent research on parent experience with prenatal professionals. Third, I outline the notions of epistemic excellence and deficiency. Fourth, I defend culpable ignorance as (...) the best explanation of inadequate disability counselling. Fifth, I rebut alternative explanations. My focus is pregnancies diagnosed with mild or moderate intellectual disability. (shrink)

Are Turgenev's novels "Rudin", "A Nest o f the Gentry", "On the Eve" and "Fathers and Sons" social chronicles or are they more celebrations of life and love? Are they paens to the nobility of the human spirit or ironic comments on human folly? These questions are addressed in this study, but is mainly concerned is that of the novels' essential character.

So much of Africana philosophical research and scholarship has focused on personal, anecdotal experiences to tell/disclose larger intellectual narratives of race, nation, history, time, and space.1 Yet the personal nature in which Africana philosophy articulates itself has often been seen as particular and not yet universal—in other words, not rightly or properly “philosophical.” But understood methodologically, the sort of introspection inherent in Africana philosophy becomes not only one way of “doing” philosophy but the grounding for philosophical insight.2 Kendrick Lamar’s album (...) good kid, m.A.A.d. city provides for us an example of such methodological insight, proper for “doing” philosophy.3In characterizing... (shrink)

In this article, I focus on three issues in Francisco Suárez’s account of the separated soul: the status of the separated soul as a person, the separated soul’s knowledge of itself, and the question of the soul’s nature both as form of the body and as existing outside the body. I place his discussion in dialogue with St. Thomas Aquinas and Cajetan (Thomas de Vio) and show the ways he departs from those two thinkers. Finally, I show that his account (...) of these problems makes for a philosophically probable account of the resurrection of the body. (shrink)

v. 1. Readings in nineteenth-century philosophy.--v. 2. Readings in twentieth-century philosophy.

Zabarella and the Intentionality of Sensation - ABSTRACT: In this paper, I examine Zabarella’s account of the intentionality of sensation. By looking at both his account of the production of the sensible species as well as proper activity of the human soul in the process of sensation, I show that he has carefully reinterpreted standard medieval theories of sensation. Most notably, his account of intentionality as a kind of mental attention seems to point towards a type of Cartesian dualism, but (...) at the same time attempts to remain faithful to the basic insights of the Aristotelian tradition concerning sensation. (shrink)

We critically examine Bermejo-Luque’s account of the logical dimension of argumentation and its logical or semantic evaluation. Our considerations concern her views on inference claims, validity, logical normativity, warrants, necessity, warrants and the justification of inferences, ontological versus epistemic modal qualifiers, ontological versus epistemic probability, and ontological versus conditional probability.